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1

Fourier spectral methods for fractional-in-space reaction-diffusion equations

Bueno-Orovio, Alfonso, Kay, David, Burrage, Kevin

Journal:

BIT Numerical Mathematics

Année:

2014

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2014

2

Minimal model for human ventricular action potentials in tissue

Alfonso Bueno-Orovio, Elizabeth M. Cherry, Flavio H. Fenton

Journal:

Journal of Theoretical Biology

Année:

2008

Langue:

english

Fichier:

PDF, 2.33 MB

english, 2008

3

Continuous Adjoint Approach for the Spalart-Allmaras Model in Aerodynamic Optimization

Bueno-Orovio, Alfonso, Castro, Carlos, Palacios, Francisco, Zuazua, Enrique

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 3.33 MB

english, 2012

4

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

Bueno-Orovio, Alfonso, Cherry, Elizabeth M., Evans, Steven J., Fenton, Flavio H.

Journal:

BioMed Research International

Année:

2015

Langue:

english

Fichier:

PDF, 3.79 MB

english, 2015

5

Spectral smoothed boundary methods: The role of external boundary conditions

Alfonso Bueno-Orovio, Víctor M. Pérez-García

Journal:

Numerical Methods for Partial Differential Equations

Année:

2006

Langue:

english

Fichier:

PDF, 853 KB

english, 2006

6

Fourier embedded domain methods: Periodic and C∞ extension of a function defined on an irregular region to a rectangle via convolution with Gaussian kernels

Alfonso Bueno-Orovio

Journal:

Applied Mathematics and Computation

Année:

2006

Langue:

english

Fichier:

PDF, 2.45 MB

english, 2006

7

Enhanced box and prism assisted algorithms for computing the correlation dimension

Alfonso Bueno-Orovio, Víctor M. Pérez-García

Journal:

Chaos, Solitons & Fractals

Année:

2007

Langue:

english

Fichier:

PDF, 486 KB

english, 2007

8

Mapped Chebyshev pseudospectral method for the study of multiple scale phenomena

Adrian Alexandrescu, Alfonso Bueno-Orovio, José R. Salgueiro, Víctor M. Pérez-García

Journal:

Computer Physics Communications

Année:

2009

Langue:

english

Fichier:

PDF, 760 KB

english, 2009

9

Na/K pump regulation of cardiac repolarization: insights from a systems biology approach

Bueno-Orovio, Alfonso, SÃ¡nchez, Carlos, Pueyo, Esther, Rodriguez, Blanca

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2014

Langue:

english

Fichier:

PDF, 540 KB

english, 2014

10

[American Institute of Aeronautics and Astronautics 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Orlando, Florida ()] 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Continuous Adjoint Approach for the Spalart-Allmaras Model in Aerodynamic Optimization

Bueno-Orovio, Alfonso, Castro, Carlos, Palacios, Francisco, Zuazua, Enrique

Année:

2011

Langue:

english

Fichier:

PDF, 408 KB

english, 2011

11

[American Institute of Aeronautics and Astronautics 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Orlando, Florida ()] 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - When the 'Exact' Discrete Gradient is not the Best Choice in Optimal Shape Design

Bueno-Orovio, Alfonso, Castro, Carlos, Duraisamy, Karthikeyan, Palacios, Francisco, Zuazua, Enrique

Année:

2011

Langue:

english

Fichier:

PDF, 529 KB

english, 2011

12

P3-24

Fenton, Flavio H., Orovio, Alfonso Bueno, Evans, Steven J., Hastings, Harold M., Cherry, Elizabeth M.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 61 KB

english, 2006

13

Spectral Methods for Partial Differential Equations in Irregular Domains: The Spectral Smoothed Boundary Method

Bueno-Orovio, Alfonso, Pérez-García, Víctor M., Fenton, Flavio H.

Journal:

SIAM Journal on Scientific Computing

Année:

2006

Langue:

english

Fichier:

PDF, 428 KB

english, 2006

14

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

Britton, Oliver J., Bueno-Orovio, Alfonso, Van Ammel, Karel, Lu, Hua Rong, Towart, Rob, Gallacher, David J., Rodriguez, Blanca

Journal:

Proceedings of the National Academy of Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2013

15

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rodriguez, Blanca, Carusi, Annamaria, Abi-Gerges, Najah, Ariga, Rina, Britton, Oliver, Bub, Gil, Bueno-Orovio, Alfonso, Burton, Rebecca A. B., Carapella, Valentina, Cardone-Noott, Louie, Daniels, Matt

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2015

16

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

Zhou, Xin, Bueno-Orovio, Alfonso, Orini, Michele, Hanson, Ben, Hayward, Martin, Taggart, Peter, Lambiase, Pier D., Burrage, Kevin, Rodriguez, Blanca

Journal:

Circulation Research

Année:

2016

Langue:

english

Fichier:

PDF, 5.93 MB

english, 2016

17

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

Muszkiewicz, Anna, Britton, Oliver J., Gemmell, Philip, Passini, Elisa, Sánchez, Carlos, Zhou, Xin, Carusi, Annamaria, Quinn, T. Alexander, Burrage, Kevin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Progress in Biophysics and Molecular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2016

18

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

Passini, Elisa, Mincholé, Ana, Coppini, Raffaele, Cerbai, Elisabetta, Rodriguez, Blanca, Severi, Stefano, Bueno-Orovio, Alfonso

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2016

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2016

19

Anomalous diffusion in cardiac tissue as an index of myocardial microstructure

Bueno-Orovio, Alfonso, Teh, Irvin, Schneider, Jurgen E., Burrage, Kevin, Grau, Vicente

Journal:

IEEE Transactions on Medical Imaging

Année:

2016

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2016

20

In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro data

Passini, Elisa, Britton, Oliver, Lu, Hua Rong, Gallacher, David J., Rohrbacher, Jutta, An, Hermans, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2016

Langue:

english

Fichier:

PDF, 68 KB

english, 2016

21

Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study

Liberos, Alejandro, Bueno-Orovio, Alfonso, Rodrigo, Miguel, Ravens, Ursula, Hernandez-Romero, Ismael, Fernandez-Aviles, Francisco, Guillem, Maria S., Rodriguez, Blanca, Climent, Andreu M.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2016

22

Reply to the Editor—On misuse of null hypothesis testing: Analysis of biophysical model simulations

Liberos, Alejandro, Bueno-Orovio, Alfonso, Rodrigo, Miguel, Ravens, Ursula, Hernandez-Romero, Ismael, Fernandez-Aviles, Francisco, Guillem, Maria S., Rodriguez, Blanca, Climent, Andreu M.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 73 KB

english, 2017

23

Exact solutions to the fractional time-space Bloch–Torrey equation for magnetic resonance imaging

Bueno-Orovio, Alfonso, Burrage, Kevin

Journal:

Communications in Nonlinear Science and Numerical Simulation

Année:

2017

Langue:

english

Fichier:

PDF, 2.52 MB

english, 2017

24

[IEEE 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Orlando, FL, USA (2016.8.16-2016.8.20)] 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart

Santos, Diogo, Orini, Michele, Zhou, Xin, Bueno-Orovio, Alfonso, Hanson, Ben, Taggart, Peter, Hayward, Martin, Rodriguez, Blanca, Lambiase, Pier

Année:

2016

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2016

25

In silico evaluation of arrhythmia

Zhou, Xin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Current Opinion in Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2018

26

In Silico Drug Trials with Virtual Assay Software Predict Drug Cardiotoxicity and Identify Sub-Populations at Higher Risk

Passini, Elisa, Britton, Oliver, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2017

Langue:

english

Fichier:

PDF, 70 KB

english, 2017

27

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

Sánchez, Carlos, Bueno-Orovio, Alfonso, Wettwer, Erich, Loose, Simone, Simon, Jana, Ravens, Ursula, Pueyo, Esther, Rodriguez, Blanca, Panfilov, Alexander V.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 3.74 MB

english, 2014

28

On the Order of the Fractional Laplacian in Determining the Spatio-Temporal Evolution of a Space-Fractional Model of Cardiac Electrophysiology

Cusimano, Nicole, Bueno-Orovio, Alfonso, Turner, Ian, Burrage, Kevin, Talkachova, Alena

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2015

29

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics

Sánchez, Carlos, Bueno-Orovio, Alfonso, Pueyo, Esther, Rodríguez, Blanca

Journal:

Frontiers in Bioengineering and Biotechnology

Année:

2017

Langue:

english

Fichier:

PDF, 5.41 MB

english, 2017

30

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Britton, Oliver J., Bueno-Orovio, Alfonso, Virág, László, Varró, András, Rodriguez, Blanca

Journal:

Frontiers in Physiology

Année:

2017

Langue:

english

Fichier:

PDF, 4.07 MB

english, 2017

31

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Passini, Elisa, Britton, Oliver J., Lu, Hua Rong, Rohrbacher, Jutta, Hermans, An N., Gallacher, David J., Greig, Robert J. H., Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Frontiers in Physiology

Année:

2017

Langue:

english

Fichier:

PDF, 3.61 MB

english, 2017

32

Virtual assay: A user-friendly framework for in silico drug trials in populations of human cardiomyocyte models

Passini, Elisa, Britton, Oliver J., Greig, Robert J.H., Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2018

Langue:

english

Fichier:

PDF, 55 KB

english, 2018

33

Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Britton, Oliver J., Bueno-Orovio, Alfonso, Virág, László, Varró, András, Rodriguez, Blanca

Journal:

Frontiers in Physiology

Année:

2017

Langue:

english

Fichier:

PDF, 132 KB

english, 2017

34

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study

Muszkiewicz, Anna, Liu, Xing, Bueno-Orovio, Alfonso, Lawson, Brodie A. J., Burrage, Kevin, Casadei, Barbara, Rodriguez, Blanca

Journal:

American journal of physiology. Heart and circulatory physiology

Année:

2018

Langue:

english

Fichier:

PDF, 12.26 MB

english, 2018

35

Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions

Cardone-Noott, Louie, Bueno-Orovio, Alfonso, Mincholé, Ana, Zemzemi, Nejib, Rodriguez, Blanca

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.14 MB

english, 2016

36

In silico electro-mechanical window shortening and repolarisation abnormalities predict clinical risk of torsade de pointes for 40 reference compounds

Passini, Elisa, Bueno-Orovio, Alfonso, Morissette, Pierre, Sannajust, Frederick, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2018

Langue:

english

Fichier:

PDF, 48 KB

english, 2018

37

Strategies of data layout and cache writing for input-output optimization in high performance scientific computing: Applications to the forward electrocardiographic problem

Cardone-Noott, Louie, Rodriguez, Blanca, Bueno-Orovio, Alfonso, Oliveira, Rafael Sachetto

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.98 MB

english, 2018

38

Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

Lawson, Brodie A., Burrage, Kevin, Burrage, Pamela, Drovandi, Christopher C., Bueno-Orovio, Alfonso

Journal:

Frontiers in Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 3.69 MB

english, 2018

39

Commentary: Atrial Rotor Dynamics Under Complex Fractional Order Diffusion

Bueno-Orovio, Alfonso

Journal:

Frontiers in Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 836 KB

english, 2018

40

Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assay

Morissette, Pierre, Gerenser, Pamela, Travis, Jeffrey, Fanelli, Patrick, Balasubramanian, Bharathi, Passini, Elisa, Bueno-Orovio, Alfonso, Rodriguez, Blanca, Regan, Christopher, Sannajust, Frederick

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2018

Langue:

english

Fichier:

PDF, 75 KB

english, 2018

41

Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities

Lyon, Aurore, Bueno-Orovio, Alfonso, Zacur, Ernesto, Ariga, Rina, Grau, Vicente, Neubauer, Stefan, Watkins, Hugh, Rodriguez, Blanca, Mincholé, Ana

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2018

42

[ - ()] - Electrophysiological Parameters in the Electrical Propagation During Atrial Fibrillation: a Population of Models Study

Simon Chica, Ana, Liberos, Alejandro, Hern�ndez-Romero, Ismael, Bueno Orovio, Alfonso, Rodrigo, Miguel, Guillem S�nchez, Maria de la Salud, Atienza, Felipe, Fern�ndez-Avil�s, Francisco, Rodriguez, Bla

Fichier:

PDF, 7 KB

43

[ - ()] - Electrophysiological Parameters in the Electrical Propagation During Atrial Fibrillation: a Population of Models Study

Simon Chica, Ana, Liberos, Alejandro, Hern�ndez-Romero, Ismael, Bueno Orovio, Alfonso, Rodrigo, Miguel, Guillem S�nchez, Maria de la Salud, Atienza, Felipe, Fern�ndez-Avil�s, Francisco, Rodriguez, Bla

Langue:

english

Fichier:

PDF, 7 KB

english

44

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

Passini, Elisa, Trovato, Cristian, Morissette, Pierre, Sannajust, Frederick, Bueno‐Orovio, Alfonso, Rodriguez, Blanca

Journal:

British Journal of Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2019

45

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

Passini, Elisa, Trovato, Cristian, Morissette, Pierre, Sannajust, Frederick, Bueno‐Orovio, Alfonso, Rodriguez, Blanca

Journal:

British Journal of Pharmacology

Année:

2019

Fichier:

PDF, 1.98 MB

2019

46

57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation?

Zhou, Xin, Harmer, Stephen, Bueno-Orovio, Alfonso, Burrage, Kevin, Tinker, Andrew, Rodriguez, Blanca

Journal:

Année:

2016

Fichier:

PDF, 115 KB

2016

47

High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence

Martinez-Navarro, Hector, Mincholé, Ana, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Scientific Reports

Année:

2019

Fichier:

PDF, 8.96 MB

2019

48

Human in silico trials on drug-induced changes in electrophysiology and calcium dynamics using the virtual assay software

Passini, Elisa, Britton, Oliver J., Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2019

Fichier:

PDF, 184 KB

2019

49

Impact of in vitro ion channel protocols when assessing cardiac pro-arrhythmic risk with in silico models

Morissette, Pierre, Imredy, John, Zhai, Jin, Travis, Jeffrey, Fanelli, Patrick, Dech, Spencer, Regan, Christopher, Bueno-Orovio, Alfonso, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2019

Fichier:

PDF, 199 KB

2019

50

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

Zhou, Xin, Qu, Yusheng, Passini, Elisa, Bueno-Orovio, Alfonso, Liu, Yang, Vargas, Hugo M., Rodriguez, Blanca

Journal:

Frontiers in Pharmacology

Année:

2020

Langue:

english

Fichier:

PDF, 5.31 MB

english, 2020